Влияние мелатонина на мужскую репродуктивную функцию (показатели эякулята)

1. Cavalhas-Almeida C., Cristo M.I., Cavadas C., Ramalho-Santos J., Alvaro A.R., Amaral S. Sleep and male (In) Fertility: A comprehensive overview. Sleep Med Rev. 2025;81:102080. doi: 10.1016/j.smrv.2025.102080.

2. Heidarizadi S., Rashidi Z., Jalili C., Gholami M. Overview of biological effects of melatonin on testis: A review. Andrologia. 2022;54(11):e14597. doi: 10.1111/and.14597.

3. Bazhenov I.V., Filippova E.S. The role of oxidative stress in the pathogenesis of male infertility. E'ffektivnaya farmakoterapiya. 2018;29:50-58. Russian (Баженов И.В., Филиппова Е.С. Роль окислительного стресса в патогенезе мужского бесплодия. Эффективная фармакотерапия. 2018;29:50-58).

4. Faniev M.V., Prokop’ev Ja.V., Kadyrov Z.A., Faustova K.V., Cherepnev G.V., Mazitova M.I. i dr. Problems and prospects of cryopreservation of human spermatozoa in modern Russia // RMZh. Medicinskoe obozrenie. 2024;8(4):215–220. Russian (Фаниев М.В., Прокопьев Я.В., Кадыров З.А., Фаустова К.В., Черепнев Г.В., Мазитова М.И. и др. Проблемы и перспективы криоконсервации сперматозоидов человека в современной России. РМЖ. Медицинское обозрение. 2024;8(4):215–220). doi: 10.32364/2587-6821-2024-8-4-5.

5. Mannucci A., Argento F.R., Fini E., Coccia M.E., Taddei N., Becatti M., Fiorillo C. The Impact of Oxidative Stress in Male Infertility. Front. Mol. Biosci. 2021;8:799294. doi: 10.3389/fmolb.2021.799294.

6. Agarwal A., Parekh N., Selvam M.K.P., Henkel R., Shah R., Homa S.T. et al. Male oxidative stress infertility (MOSI): proposed terminology and clinical practice guidelines for management of idiopathic male infertility. World J men’s Health. 2019;37:296–312. doi: 10.5534/wjmh.190055.

7. Ovchinnikov R.I. Male infertility associated with oxidative stress of spermatozoa: pathogenesis and therapeutic approach. Medicinskij sovet. 2022;16(5):46-53. Russian (Овчинников Р.И. Мужское бесплодие, связанное с окислительным стрессом сперматозоидов: патогенез и терапевтический подход. Медицинский совет. 2022;16(5):46-53). https://doi.org/10.21518/2079-701X-2022-16-5-46-53.

8. Jing J., Peng Y., Fan W., Han S., Peng O., Xue C. et al. Obesity-induced oxidative stress and mitochondrial dysfunction negatively affect sperm quality. FEBS Open Bio. 2023;13(4):763-778. doi: 10.1002/2211-5463.13589.

9. Bravo A., Sanchez R., Zambrano F., Uribe P. Exogenous Oxidative Stress in Human Spermatozoa Induces Opening of the Mitochondrial Permeability Transition Pore: Effect on Mitochondrial Function, Sperm Motility and Induction of Cell Deat. Antioxidants (Basel). 2024;13(6):739. doi: 10.3390/antiox13060739.

10. Takeshima T., Usui K., Mori K., Asai T., Yasuda K., Kuroda S. et al. Oxidative stress and male infertility. Reprod Med Biol. 2021;20:41–52. doi: 10.1002/rmb2.12353.

11. Hai E., Li B., Zhang J., Zhang J. Sperm freezing damage: the role of regulated cell death. Cell Death Discov. 2024;10(1):239. doi: 10.1038/s41420-024-02013-3.

12. Dutta S., Sengupta P., Samrot A.V. Physiological and pathological functions of reactive nitrogen species (RNS) and reactive sulphur species (RSS) on male reproductive functions. J Integrated Sci Technology. 2024;12:755. doi: 10.62110/ sciencein.jist.2024.v12.755.

13. Agarwal A., Sengupta P. Oxidative stress and its association with male infertility. Male infertility: Contemp Clin approaches andrology ART antioxidants. 2020. doi: 10.1007/978-3-030-32300-4_6.

14. Sengupta P., Dutta S., Irez T. Oxidants and antioxidants in male reproduction: roles of oxidative and reductive stress. J Integrated Sci Technology. 2024;12:753. doi: 10.62110/sciencein.jist.2024.v12.753.

15. Agarwal A., Rana M., Qiu E., AlBunni H., Bui A.D., Henkel R. Role of oxidative stress, infection and inflammation in male infertility. Andrologia. 2018;50:13126. doi: 10.1111/and.13126.

16. Ebrahimi N.D., Sadeghi A., Ala M., Ebrahimi F., Pakbaz S., Azarpira N. Protective effects of melatonin against oxidative stress induced by metabolic disorders in the male reproductive system: a systematic review and meta-analysis of rodent models. Front Endocrinol (Lausanne). 2023;14:1202560. doi: 10.3389/ fendo.2023.1202560.

17. Eini F., Kutenaei M.A., Shirzeyli M.H., Dastjerdi Z.S., Omidi M., Novin M.G. Normal seminal plasma could preserve human spermatozoa against cryopreservation damages in Oligozoospermic patients. BMC Mol Cell Biol. 2021;22(1):50. doi: 10.1186/s12860-021-00390-6.

18. Choi H.W., Jang H. Application of Nanoparticles and Melatonin for Cryopreservation of Gametes and Embryos. Curr Issues Mol Biol. 2022;44(9):4028-4044. doi: 10.3390/cimb44090276.

19. Shaty'lko T.V., Gamidov S.I., Tambiev A.X., Safiullin R.I., Safiullin R.I., Popova A.Yu. The use of assisted reproductive technologies in complex forms of male infertility and azoospermia. Farmakologiya & Farmakoterapiya. 2022;3:10-16. Russian (Шатылко Т.В., Гамидов С.И., Тамбиев А.Х., Сафиуллин Р.И., Попова А.Ю. Применение вспомогательных репродуктивных технологий при сложных формах мужского бесплодия и азооспермии. Фармакология & Фармакотерапия. 2022;3:10-16). doi: 10.46393/27132129_2022_3_10.

20. Yang X., Chen Y., Song W., Huang T., Wang Y., Chen Z. et al. Review of the Role of Ferroptosis in Testicular Function. Nutrients. 2022;14:5268. doi: 10.3390/nu14245268.

21. Sun T.C., Li D.M., Yu H., Song L.L., Jia Y.J., Lin L. et al. Bilateral varicocele leads to ferroptosis, pyroptosis and necroptosis of human spermatozoa and affects semen quality in infertile men. Front. Cell Dev. Biol. 2023;11:1091438. doi: 10.3389/fcell.2023.1091438.

22. Zhao Y., Qin G., Jiang B., Huang J., He S., Peng H. Melatonin regulates mitochondrial function to alleviate ferroptosis through the MT2/Akt signaling pathway in swine testicular cells. Sci Rep. 2024;14(1):15215. doi: 10.1038/s41598-024-65666-1.

23. Zhang D., Li Y., Du C., Sang L., Liu L., Li Y. et al. Evidence of pyroptosis and ferroptosis extensively involved in autoimmune diseases at the single-cell transcriptome level. J. Transl. Med. 2022;20:363. doi: 10.1186/s12967-022-03566-6.

24. Moretti E., Signorini C., Corsaro R., Giamalidi M., Collodel G. Human Sperm as an In Vitro Model to Assess the Efficacy of Antioxidant Supplements during Sperm Handling: A Narrative Review. Antioxidants (Basel). 2023;12(5):1098. doi: 10.3390/antiox12051098.

25. Nakidkina A.N., Kuz'mina T.I. Sperm apoptosis and its role in reducing semen quality. Ontogenez. 2019;50(4):219-227. Russian (Накидкина А.Н., Кузьмина Т.И. Апоптоз сперматозоидов и его роль в снижении качества семени. Онтогенез. 2019;50(4):219-227). doi: 10.1134/S0475145019040062.

26. ELkamshoushi A., Hussein O., Elemam A., Omar S.S. The Role of Apoptosis and Reactive Oxygen Species in Varicocele-Associated Azoospermia. Archives of Urology. 2018;1(1):22-28. doi:10.22259/2638-5228.0101005.

27. Bely'j L.E. Melatonin and male infertility caused by oxidative stress. Andrologiya i genital'naya xirurgiya. 2024;25(3):15-23. Russian (Белый Л.Е. Мелатонин и мужское бесплодие, вызванное окислительным стрессом. Андрология и генитальная хирургия. 2024;25(3):15-23). doi: https://doi.org/10.62968/2070-9781-2024-25-3-15-23.

28. Agarwal A., Leisegang K., Majzoub A., Henkel R., Finelli R., Selvam M.K.P. et al. Utility of antioxidants in the treatment of male infertility: clinical guidelines based on a systematic review and analysis of evidence. World J men’s Health. 2021;39:233. doi: 10.5534/wjmh.200196.

29. Moradi M., Hashemian M.A., Fathi M., Peysokhan M., Hashemian A.H., Moradi B. et al. Utility of vitamin C in ameliorating citalopram-induced testicular toxicity via modulating nitro-oxidative stress and apoptosis in mice. J Biochem Mol Toxicol. 2024;38(1):23543. doi: 10.1002/jbt.23543.

30. Lucignani G., Jannello L.M.I., Fulgheri I., Silvani C., Turetti M., Gadda F. et al. Coenzyme Q10 and Melatonin for the Treatment of Male Infertility: A Narrative Review. Nutrients. 2022;14(21):4585. doi: 10.3390/nu14214585.

31. Shilova A.V., Anan'eva N.I., Safonova N.Yu., Lukina L.V. Epiphysis: structural variants and their role in the occurrence of neurological and mental disorders. Annaly' klinicheskoj i e'ksperimental'noj nevrologii. 2022;16(1):39-45. Russian (Шилова А.В., Ананьева Н.И., Сафонова Н.Ю., Лукина Л.В. Эпифиз: варианты строения и их роль в возникновении неврологических и психических расстройств. Анналы клинической и экспериментальной неврологии. 2022;16(1):39-45). doi: https://doi.org/10.54101/ACEN.2022.1.5.

32. Amer M.E., Othman A.I., Abozaid H.M., El-Missiry M.A. Utility of melatonin in mitigating ionizing radiation-induced testis injury through synergistic interdependence of its biological properties. Biol Res. 2022;55(1):33. doi: 10.1186/s40659-022-00401-6.

33. Du C.Q., Yang Y.Y., Chen J., Feng L., Lin W-Q. Association between sleep quality and semen parameters and reproductive hormones: a cross-sectional study in Zhejiang, China. Nat Sci Sleep. 2020;12:11–18. doi: 10.2147/NSS.S235136.

34. Awad H., Halawa F., Mostafa T., Atta H. Melatonin hormone profile in infertile males. Int J Androl. 2006;29(3):409-413. doi: 10.1111/j.1365-2605.2005.00624.x.

35. Bocheva G., Bakalov D., Iliev P., Tafradjiiska-Hadjiolova R. The Vital Role of Melatonin and Its Metabolites in the Neuroprotection and Retardation of Brain Aging. Int J Mol Sci. 2024;25(10):5122. doi: 10.3390/ijms25105122.

36. Makris A., Alevra A.I., Exadactylos A., Papadopoulos S. The Role of Melatonin to Ameliorate Oxidative Stress in Sperm Cells. Int J Mol Sci. 2023;24(20):15056. doi: 10.3390/ijms242015056.

37. Sun T.C., Li H.Y., Li X.Y., Yu K., Deng S.L., Tian L. Protective effects of melatonin on male fertility preservation and reproductive system. Cryobiology. 2020;95:1–8. doi: https://doi.org/10.1016/J.CRYOBIOL.2020.01.018.

38. Cipolla-Neto J., Amaral F.G., Soares J.M., Gallo C.C., Furtado A., Cavaco J.E. et al. The crosstalk between melatonin and sex steroid hormones. Neuroendocrinology. 2022;112:115–29. https://doi.org/10.1159/000516148.

39. Niu P., Huang F., Wang j., Suo J-J., Wang J-R., Fang D. et al. Effects of melatonin on sperm quality, enzyme activity, antioxidant gene expression and fertility of cryopreserved bovine semen. Theriogenology. 2024;226:104-109. doi: 10.1016/j.theriogenology.2024.06.002.

40. Hajam Y.A., Rai S., Ghosh H., Basheer M. Combined administration of exogenous melatonin and insulin ameliorates streptozotocin induced toxic alteration on hematological parameters in diabetic male wistar rats. Toxicol Rep.2020;7:353–359. doi: 10.1016/j.toxrep.2020.01.020.

41. Yang M., Guan S., Tao J., Zhu K., Lv D., Wang J. et al. Melatonin promotes male reproductive performance and increases testosterone synthesis in mammalian Leydig cellsdagger. Biol Reprod. 2021;104:1322–1336. doi: 10.1093/biolre/ioab046.

42. Malmir M., Noreini S.N., Ghafarizadeh A., Faraji T., Asaliet Z. Ameliorative effect of melatonin on apoptosis, DNA fragmentation, membrane integrity and lipid peroxidation of spermatozoa in the idiopathic asthenoteratospermic men: in vitro. Andrologia. 2021;53. https://doi.org/10.1111/and.13944.

43. Riviere E., Rossi S.P., Tavalieri Y.E., Munoz de Toro M.M., Ponzio R., Puigdomenech E. et al. Melatonin daily oral supplementation attenuates inflammation and oxidative stress in testes of men with altered spermatogenesis of unknown aetiology. Mol Cell Endocrinol. doi: 10.1016/j.mce.2020.110889.

44. Alevra A.I., Exadactylos A., Mente E., Papadopoulos S. The Protective Role of Melatonin in Sperm Cryopreservation of Farm Animals and Human: Lessons for Male Fish Cryopreservation. Animals. 2022, 12, 791. doi: 10.3390/ani12060791.

45. Feng T.Y., Li Q., Ren F., Xi H-M., Lv D-L., Li Y. et al. Melatonin Protects Goat Spermatogonial Stem Cells against Oxidative Damage during Cryopreservation by Improving Antioxidant Capacity and Inhibiting Mitochondrial Apoptosis Pathway. Oxid. Med. Cell. Longev. 2020;2020:5954635. doi: 10.1155/2020/5954635.

46. Monteiro K.S., Motta N.C., Cardoso A.C.P., Souza S.P., Murgas L.D.S. Melatonin Supplementation for the Cryopreservation of Canine Sperm. Biopreserv Biobank. 2023;21(5):477-482. doi: 10.1089/bio.2022.0009.

47. Felix F., Ferrao L., Gallego V., Oliveira C.C.V., Cabrita E. Melatonin production improves Senegalese sole sperm motility at night, but fails as a supplement during cryopreservation Cryobiology. 2024;117:104974. doi: 10.1016/j.cryobiol.2024.104974.

48. Grover P., Singh A.K., Kumar A., Honparkhe M., Singh N., Singh P. Effect of exogenous melatonin implant on post-thaw semen quality of buffalo bulls. Reprod Domest Anim. 2024;59(4):e14562. doi: 10.1111/rda.14562.

49. Karimfar M.H., Niazvand F., Haghani K., Ghafourian S., Shirazi R., Bakhtiyari S. The protective effects of melatonin against cryopreservation-induced oxidative stress in human sperm. Int J Immunopathol Pharmacol. 2015;28(1):69-76. doi: 10.1177/0394632015572080.

50. Tajabadi E., Javadi A., Azar N.A., Najafi M., Shirazi A., Shabeeb D. et al. Radioprotective efect of a combination of melatonin and metformin on mice spermatogenesis: a histological study. Int J Reprod Biomed. 2020;18:1073–1080. doi: 10.18502/ijrm.v18i12.8029.

51. Kesari K.K., Agarwal A., Henkel R. Radiations and male fertility. Reprod Biol Endocrinol. 2018;16(1):118. doi: 10.1186/s12958-018-0431-1.

52. Yardim A., Sirav B., Tomruk A., Oruc S., Delen K., Kuzay D. et al. The histological and biochemical analysis of the effects of radiofrequency radiation on testis tissue of rats and the protective effect of melatonin. Turk J Med Sci. 2024;54(4):858-865. doi: 10.55730/1300-0144.5857.

53. Pandey N., Giri S. Melatonin attenuates radiofrequency radiation (900 MHz)-induced oxidative stress, DNA damage and cell cycle arrest in germ cells of male Swiss albino mice. Toxicol Ind Health. 2018 May;34(5):315-327. doi: 10.1177/0748233718758092.

54. Wang Z., Teng Z., Wang Z., Song Z., Zhu P., Li N. et al. Melatonin ameliorates paclitaxel-induced mice spermatogenesis and fertility defects. J Cell Mol Med. 2022;26(4):1219-1228. doi: 10.1111/jcmm.17177.

55. Zi T., Liu Y., Zhang Y., Wang Z., Wang Z., Zhan S. et al. Protective effect of melatonin on alleviating early oxidative stress induced by DOX in mice spermatogenesis and sperm quality maintaining. Reprod Biol Endocrinol. 2022;20(1):105. doi: 10.1186/s12958-022-00977-4.

56. Moradi M., Goodarzi N., Faramarzi A., Cheraghi H., Hashemian A.H., Jalili C. Melatonin protects rats testes against bleomycin, etoposide, and cisplatin-induced toxicity via mitigating nitro-oxidative stress and apoptosis. Biomed Pharmacother. 2021;138:111481. doi: 10.1016/j.biopha.2021.111481.

57. Armandeh M., Bameri B., Haghi-Aminjan H., Foroumadi R., Ataei M., Hassani S. et al. A systematic review on the role of melatonin and its mechanisms on diabetes-related reproductive impairment in non-clinical studies. Front Endocrinol (Lausanne). 2022;13:1022989. doi: 10.3389/fendo.2022.1022989.

58. Ezzat W., Abdelbasset W.K., Hussien R.S., Azab A.R., Sulieman A., Yousry S. Effect melatonin on reproductive function in propylthiouracil induced hypothyroidism in adult male rats. Eur Rev Med Pharmacol Sci. 2024;28(5):1920-1930. doi: 10.26355/eurrev_202403_35606.

59. Zhang P., Zheng Y., Lv Y., Li F., Su L., Qinet Y. et al. Melatonin protects the mouse testis against heat-induced damage. Mol Hum Reprod. 2020;26:65–79 doi: 10.1093/molehr/gaaa002.

60. Guo Y., Chen H., Wang Q.J., Qi X., Li Q., Fu W. et al. Prolonged melatonin treatment promote testicular recov ery by enhancing RAC1-mediated apoptotic cell clearance and cell junction-dependent spermatogensis after heat stress. Theriogenology. 2021;162:22-31. doi: 10.1016/j.theriogenology.2020.12.015.