Based on the literature data, this review discusses the prevalence and etiology of male infertility, as well as the current view of the reasons for the lack of effectiveness of treatment of idiopathic infertility in men. The effectiveness of antioxidant therapy in various variants of redox balance disorders is evaluated. Possible prerequisites and mechanisms of complications in the administration of antioxidants are described. In addition, the need to introduce laboratory confirmation of oxidative stress and review approaches to antioxidant therapy is justified. The article also discusses the possibility of treating idiopathic pathospermia with the help of a complex drug Androdoz, which, according to the literature, can improve such indicators of sperm as the volume of ejaculate, the number and viability of spermatozoa and the proportion of their actively mobile forms due to the synergy of its components.

Keywords: Androdose, reductive stress, male infertility, antioxidants, oxidative stress