Русский
The features of the pathologic changes in chronic oxalate stone disease after 16 week of experimental phase
DOI: https://dx.doi.org/10.18565/urology.2018.5.13-15
G.V. Zharikova, V.M. Bryukhanov, A.I. Neymark, A.Yu. Zharikov, I.P. Bobrov., N.N. Yakushev
FGBOU VO «Altai State Medical University» of the Ministry of Health of Russia, Barnaul, Russia
Aim. to study the pathologic features of chronic oxalate stone disease.
Materials and methods. a model of the experimental oxalate stone disease was done in rats that drank the 1% ethylene glycol solution for 16 weeks. The pathologic analysis of the rats’ kidneys was done.
Results. After 16 weeks of oxalate stone disease modeling in all parts of kidneys the large crystals deposits were found, which plugged renal tubules. Moreover, purulent calculous pyelonephritis developed complicated by fibrosis.
Materials and methods. a model of the experimental oxalate stone disease was done in rats that drank the 1% ethylene glycol solution for 16 weeks. The pathologic analysis of the rats’ kidneys was done.
Results. After 16 weeks of oxalate stone disease modeling in all parts of kidneys the large crystals deposits were found, which plugged renal tubules. Moreover, purulent calculous pyelonephritis developed complicated by fibrosis.
About the Autors
Corresponding author: G.V. Zharikova – Lecturer at the Department of General and Biological Chemistry, clinical diagnostic laboratory of FGBOU VO «Altai State Medical University» of the Ministry of Health of Russia, Barnaul, Russia; е-mail: ganna1704@mail.ru
