Introduction. Barren marriage is an important medical and social problem. Up to 20-60% of cases of male infertility are associated with inflammatory diseases of the reproductive system. Chronic prostatitis constitutes up to 50% cases. In this regard, a search of methods aimed at improvement of detection rate of pathogens in inflammatory prostatic diseases of the prostate is still relevant.
Aim: To study the influence of bovhyaluronidaze azoximer (Longidaza®) on the diagnostic sensitivity of semen culture in infertile men.
Materials and methods: a total of 87 infertile men were included in the study. The main group consisted of 41 patients who received Longidaza® 3000 IU, one suppository every two days, for a total of 5 suppositories, prior to semen culture. In the control group, 46 patients had semen culture without any interventions. When evaluating the result of semen culture, clinically significant bacterial count was ≥103 CFU/ml.
Results. In the main group, bacterial growth was seen in 19 (46.3%) patients, which is 2.7 times higher than in the control group (n=8; 17.4%; χ2=4.47, p=0.0346). A total of 36 patients in the control group with negative semen culture at baseline undergone to repeat analysis, according to the protocol in the main group. As a result, in 12 more patients in the control group (33% men with initially negative semen analysis) a bacterial growth was shown. The detection rate of bacteria in the ejaculate in the control group after repeat analysis was similar to those in the main group (43.5 и 46.3%, respectively, р=0.87).
Conclusion. The preliminary use of bovhyaluronidaze azoximer rectal suppositories (Longidaza®) in infertile men, when they undergone diagnostic evaluation, contributes to increase in diagnostic sensitivity of semen culture and allows to improve the quality of diagnosis of the inflammatory diseases of reproductive system.

Keywords: microbiological study, bovhyaluronidaze azoximer, male infertility