Русский
D-mannose for prevention and treatment of lower urinary tract infection: pathogenetic basics and clinical results
DOI: https://dx.doi.org/10.18565/urology.2020.4.131-138
I.V. Kuz'min, M.N. Slesarevskaya, S.H. Al-Shukri
1) Department of Urology of First Pavlov Saint-Petersburg State Medical University of the Ministry of Healthcare of the Russian Federation, Saint Petersburg, Russia; 2) Scientific and Research Center of Urology in Scientific and Research Institute for Surgery and Emergency Medicine of First Pavlov Saint-Petersburg State Medical University of the Ministry of Healthcare of the Russian Federation, Saint Petersburg, Russia
Non-antibacterial methods of prevention and treatment of lower urinary tract infection are described in the article. The current view on the mechanism of treatment effect of D-mannose is presented, which contributes to the prevention of bacterial invasion. Pathogenetic concepts for using D-mannose as specific antiadhesin or a competitive blocker of bacterial invasion is provided. In addition, we discussed the results of basic and clinical studies, proving the efficiency of D-mannose for prevention and treatment of lower urinary tract infection.
Keywords: D-mannose, Escherichia coli, lower urinary tract infection, acute cystitis, recurrent cystitis
About the Autors
Corresponding author: I.V. Kuz'min– MD, professor of the Department of Urology of First Pavlov Saint-Petersburg State Medical University of the Ministry of Healthcare of the Russian Federation, Saint Petersburg, Russia; e-mail: kuzminigor@mail.ru
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