Русский
Experimental study on the efficiency of rectal suppositories with oxidized dextran in patients with benign prostatic hyperplasia
DOI: https://dx.doi.org/10.18565/urology.2021.5.59-61
E.G. Novikova, A.V. Troitsky, H.U. Ukah, V.G. Selyatitskaya
1) Federal State Budget Scientific Institution “Federal Research Center of Fundamental and Translational Medicine”, Novosibirsk, Russia; 2) Regional Medical and Diagnostic Centre Ltd, Novosibirsk, Russia
Aim: to evaluate therapeutic activity of oxidized dextran after rectal administration in a modified sulpiride model of benign prostatic hyperplasia in mice.
Materials and methods: The therapeutic activity of oxidized dextran was studied in an experimental model of benign prostatic hyperplasia in mice (sulpiride model). All in vivo studies were carried out on 30 male BALB/c mice with an average body weight of 30–35 g.
Results: It was found that rectal administration of a solution of oxidized dextran effectively neutralizes pathomorphological changes in experimental model of benign prostatic hyperplasia. In the group of animals, which received 2% solution of oxidized dextran as treatment, the most prominent therapeutic effect in an experimental model was seen and it was confirmed by a decrease in the bladder detrusor thickness and the normalization of its lumen.
Materials and methods: The therapeutic activity of oxidized dextran was studied in an experimental model of benign prostatic hyperplasia in mice (sulpiride model). All in vivo studies were carried out on 30 male BALB/c mice with an average body weight of 30–35 g.
Results: It was found that rectal administration of a solution of oxidized dextran effectively neutralizes pathomorphological changes in experimental model of benign prostatic hyperplasia. In the group of animals, which received 2% solution of oxidized dextran as treatment, the most prominent therapeutic effect in an experimental model was seen and it was confirmed by a decrease in the bladder detrusor thickness and the normalization of its lumen.
Keywords: oxidized dextran, benign prostatic hyperplasia
About the Autors
Corresponding author: E.G. Novikova – Ph.D., Senior Researcher of Endocrinology Laboratory of Federal Research Center of Fundamental and Translational Medicine; urologist and andrologist, Regional Medical and Diagnostic Centre Ltd, Novosibirsk, Russia; e-mail: rmdc.nsk@gmail.com
