Introduction. The problem of male infertility is multifactorial. However, in recent years, the involvement of viruses, in particular human papillomaviruses (HPV), in the development of this condition has been actively discussed.
Purpose of the study: to study the effect of HPV in mono and mixed versions on ejaculate parameters.
Materials and methods. We analyzed the results of a survey of 105 patients aged from 22 to 40 years (average age – 32.3±6.4) with a diagnosis of infertility and pathospermia combined with PVI, with the absence of other risk factors.
Results. The presence of several viruses in the ejaculate increased the degree of biochemical and cytopathomorphological disorders of sperm recorded in patients with HPV-associated infertility.
Conclusions. a combination of several types of virus leads to a deterioration in the functional activity of Leydig and Sertoli cells of the testicles, characterized by a decrease in the synthesis of total testosterone levels and the development of qualitative and quantitative disorders of the ejaculate. This circumstance is due to the fact that with the association of several microorganisms, there is most likely an increase in the pathogenic potential of HPV.

Keywords: ejaculate, sperm, human papillomavirus, infertility