Маркеры рака предстательной железы и потенциал использования АПФ, вырабатываемого простатой, в диагностике рака предстательной железы и доброкачественной гиперплазии предстательной железы


DOI: https://dx.doi.org/10.18565/urology.2019.2.73-81

А.А. Камалов, Л.М. Самоходская, В.К. Карпов, Д.А. Охоботов, В.Н. Мамедов

1) Факультет фундаментальной медицины МГУ им. М. В. Ломоносова, кафедра урологии и андрологии (зав. каф. – акад. РАН, проф., д.м.н. А. А. Камалов), Москва, Россия; 2) МНОЦ МГУ им. М. В. Ломоносова (директор – акад. РАН, проф., д.м.н. А. А. Камалов), Москва, Россия; 3) ГБУЗ «ГКБ № 31» ДЗМ (глав. врач – к.м.н. Н. М. Ефремова), Москва, Россия
Рак предстательной железы (РПЖ) – четвертое по частоте онкологическое заболевание у мужчин, частота его выявления на различных стадиях увеличивается с каждым годом. Успех лечения рака простаты напрямую зависит от того, насколько своевременно диагностировано заболевание. Наиболее применимым и единым во всем мире маркером рака простаты является простат-специфический антиген (ПСА). Ввиду недостаточной достоверности исследования крови на ПСА, особенно у пациентов с показателями от 4,5 до 10 нг/мл в возрасте более 50 лет, необходим поиск новых веществ, циркулирующих в крови, которые могли бы стать новыми маркерами РПЖ.
В данной статье обобщены накопленные данные о различных потенциальных маркерах, подчеркнута потенциальная роль использования ангеотензин-превращающего фермента (АПФ) в качестве нового маркера РПЖ.

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Об авторах / Для корреспонденции


А в т о р д л я с в я з и: В. Н. Мамедов – аспирант кафедры урологии и андрологии факультета фундаментальной
медицины МГУ им. М. В. Ломоносова, Москва, Россия; e-mail: mvadim_91@yahoo.com


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