A role of fesoterodine in treatment of overactive bladder
DOI: https://dx.doi.org/10.18565/urology.2018.6.155-162
Yu.A. Kupriyanov, G.R. Kasyan, D.Yu. Pushkar
Department of Urology of Federal State Budgetary Educational Institution of Higher Education «A.I. Evdokimov Moscow State University of Medicine and Dentistry» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia
The muscarinic receptors have been used as target in treatment of overactive bladder (OAB) for a long time. These patients have complaints of urgency, increased urinary frequency and nocturia, sometimes with urinary incontinence (involuntary urine leakage which is associated with abrupt and strong desire to void). Fesoterodine is a prodrug that is structurally and functionally associated with tolterodine and it is the novel drug for OAB treatment. As a result of fesoterodine cleavage by non-specific esterase, the active metabolite 5-hydroxymethyl tolterodine (5-HMT) is formed.
Like other antimuscarinic drugs, fesoterodine allows to improve bladder storage function (reducing the frequency of urination) and urgency. For assessing an improvement of the quality of life after treatment by fesoterodine the KHQ questionnaire was used.
About the Autors
Corresponding author: Yu.A. Kupriyanov – Cand.Med.Sci., assistant at the Department of Urology of A.I. Evdokimov Moscow State University of Medicine and Dentistry, urologist at the Municipal clinical hospital named after S.I. Spasokukotskiy, Moscow, Russia; e-mail: Dr.kupriyanov@gmail.com
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