Русский
Antioxidant therapy improves the results of НВА-test in infertile men during a preparation for assisted reproductive technology (IVF/ICSI)
DOI: https://dx.doi.org/10.18565/urology.2019.16.90-96
A.Yu. Popova, R.I. Ovchinnikov, S.I. Gamidov
Department of Andrology and Urology of National Medical Research Center of Obstetrics, Gynecology and Perinatology named after V.I. Kulakov of the Ministry of Health of Russia, Moscow, Russia
Introduction. Male infertility accounts for 45–50% of all barren marriages, and in up to 40% of cases an idiopathic male infertility is diagnosed. The introduction of ART programs into clinical practice allowed to restore the childbearing function in various diseases, both in women and men, which were previously considered absolutely unpromising for treatment.
Aim: to study an influence of the antioxidant complex (Androdoz) on the results of HBA-test in infertile men during a preparation for assisted reproductive technology (IVF/ICSI).
Materials and methods. A total of 80 men aged from 25 to 45 years planning an ART program were included in a comparative, randomized, prospective, controlled study. Sixty men in a main group received an antioxidant complex (Androdoz) for 3 months, while 20 men were allocated to control group. The criterion of efficiency of the treatment was an improvement of HBA-test as well as pregnancy rate in the couples determined by interviewing patients participating in the study.
Results. After 3 months of therapy an increase in the number of morphologically normal spermatozoa in the ejaculate was shown in the main group, while in the control group negative changes were noted. There was a decrease in the proportion of spermatozoa with a progressive movement (А+В) in comparison with the control group. A positive influence of antioxidant complex (Androdoz) on the functional properties of sperm was proven by the increase in HBA-test by 13.8%, whereas there were no positive changes in the control group. A pregnancy rate after the first cycle of ART in the main group was 45% compared to 25% in the control group.
Conclusion. The use of the antioxidant complex (Androdoz) for the treatment of male infertility in those patients who considers ART program is perspective method which allows to improve the main criteria of sperm analysis and functional tests (HBA-test), and also contributes to an increase in positive outcomes of ART program.
Aim: to study an influence of the antioxidant complex (Androdoz) on the results of HBA-test in infertile men during a preparation for assisted reproductive technology (IVF/ICSI).
Materials and methods. A total of 80 men aged from 25 to 45 years planning an ART program were included in a comparative, randomized, prospective, controlled study. Sixty men in a main group received an antioxidant complex (Androdoz) for 3 months, while 20 men were allocated to control group. The criterion of efficiency of the treatment was an improvement of HBA-test as well as pregnancy rate in the couples determined by interviewing patients participating in the study.
Results. After 3 months of therapy an increase in the number of morphologically normal spermatozoa in the ejaculate was shown in the main group, while in the control group negative changes were noted. There was a decrease in the proportion of spermatozoa with a progressive movement (А+В) in comparison with the control group. A positive influence of antioxidant complex (Androdoz) on the functional properties of sperm was proven by the increase in HBA-test by 13.8%, whereas there were no positive changes in the control group. A pregnancy rate after the first cycle of ART in the main group was 45% compared to 25% in the control group.
Conclusion. The use of the antioxidant complex (Androdoz) for the treatment of male infertility in those patients who considers ART program is perspective method which allows to improve the main criteria of sperm analysis and functional tests (HBA-test), and also contributes to an increase in positive outcomes of ART program.
About the Autors
Corresponding author: A.Yu. Popova – Ph.D., senior researcher, Department of Andrology and Urology of National Medical Research Center of Obstetrics, Gynecology and Perinatology named after V.I. Kulakov of the Ministry of Health of Russia, Moscow, Russia; assistant professor at the Department of Obstetrics, Gynecology, Perinatology and Reproductology of National Medical Research Center of Obstetrics, Gynecology and Perinatology named after V.I. Kulakov of the Ministry of Health of Russia, Moscow, Russia; e-mail: a_popova@oparina4.ru
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