Русский
Molecular basis of intratumoral heterogeneity of urinary tract urothelial carcinoma
DOI: https://dx.doi.org/10.18565/urology.2019.1.126-130
Y.I. Osmanov, J.A. Gaibov, E.A. Kogan, L.M. Rapoport
1) Department of Pathology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia; 2) Department of Pathology, Scientific Clinical Center of Russian Railways, Moscow, Russia; 3) Department of Urology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia
In the article the main mechanisms of molecular pathogenesis of urinary tract urothelial carcinoma are presented. Two different molecular pathways that determine the development of non-invasive and invasive urothelial carcinoma, the immunohistochemical spectrum of stem markers and aspects of the carcinogenesis of multifocal and recurrent tumors are considered.
About the Autors
Corresponding author: Y.I. Osmanov – head of the Department of Pathology of Scientific Clinical Center of Russian Railways; assistant professor of Department of Pathology named after A.I. Strukov of I.M. Sechenov First Moscow State Medical University, Moscow, Russia; e-mail: osmanovyouseef@yandex.ru
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