Молекулярные основы внутриопухолевой гетерогенности уротелиальных карцином мочевыделительной системы


DOI: https://dx.doi.org/10.18565/urology.2019.1.126-130

Ю.И. Османов, Ж.А. Гаибов, Е.А. Коган, Л.М. Рапопорт

1) Кафедра патологической анатомии ГБОУ «Первый государственный медицинский университет им. И. М. Сеченова», Москва, Россия; 2) отделение патологической анатомии Научного клинического центра ОАО РЖД, Москва, Россия; 3) кафедра урологии ГБОУ «Первый государственный медицинский университет им. И. М. Сеченова», Москва, Россия
В статье представлены основные молекулярные механизмы патогенеза уротелиального рака мочевыделительной системы. Рассмотрено два молекулярных пути, определяющих развитие поверхностной и инвазивной уротелиальной карциномы, иммуногистохимический спектр стволовых маркеров и аспекты канцерогенеза множественных и рецидивных опухолей.

Литература


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Об авторах / Для корреспонденции


А в т о р д л я с в я з и: Ю. И. Османов – к.м.н., заведующий патологоанатомическим отделением НУЗ НКЦ ОАО РЖД;
доцент кафедры патологической анатомии им. А И. Струкова ГБОУ Первый медицинский университет
им. И. М. Сеченова (Сеченовский Университет), Москва, Россия; e-mail: osmanovyouseef@yandex.ru


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