Русский
Premature ejaculation: the main physiological mechanisms and new approaches to the treatment
DOI: https://dx.doi.org/10.18565/urology.2020.6.95-102
A.A. Kamalov, D.A. Ohobotov, M.V. Frolova, A.S. Tivtikyan, O.Y. Nesterova
1) Moscow Research and Education Center of the Lomonosov Moscow State University (Director – Academician of the RAS, Dr.Med.Sci. Kamalov A.A.) Moscow Research and Education; 2) Lomonosov Moscow State University, Faculty of Fundamental Medicine, Urology and Andrology Department (Head of the Department – Academician of the RAS, Dr.Med.Sci. Kamalov A.A.); 3) Lomonosov Moscow State University, Faculty of Fundamental Medicine
Premature ejaculation (PE) is characterized by an early ejaculation, which occurs within 1 minute after or before vaginal penetration. PE is the most common sexual problem and leads to a number of negative psychological consequences. To understand the etiopathogenesis of PE, it is necessary to understand the physiological mechanisms of the ejaculatory reflex. A group of galanine-ergic lumbar spinothalamic cells (LSt cells) with their numerous projections to various structures of the central nervous system plays a crucial role. The main approaches to the treatment of PE are based on the inhibition of glans sensitivity. In recent years, most of the studies on PE are dedicated to various technologies of reflexotherapy and a possibility of biofeedback. We have analyzed the available literature data and explained the main links of ejaculatory reflex, as well as possible approaches to treatment.
Keywords: rehabilitation therapy, galanin, lumbar spinothalamic cells, LSt cells, biofeedback, premature ejaculation, acupuncture
About the Autors
Corresponding author: D.A. Ohobotov − Ph.D. (Med.), Urologist, Medical Research and Education Center, Lomonosov Moscow State University University, Senior Lecturer, Andrology and Urology Faculty of Fundamental Medicine, Lomonosov Moscow State University Lomonosov, Moscow, Russia; е-mail: 14072003@rambler.ru
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