Русский
Acute kidney injury in COVID-19: clinical and morphological comparisons based on autopsy data
DOI: https://dx.doi.org/10.18565/urology.2020.6.5-10
M.V. Kovylina, O.I. Astakhova, O.V. Zayratyants, E.A. Prilepskaya, L.V. Reshetov, K.B. Kolontarev, D.Yu. Pushkar
1) Department of Urology of A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia; 2) Municipal clinical hospital named after S.I. Spasokukotskiy of the Moscow Healthcare Department, Moscow, Russia; 3) Department of Pathologic Anatomy of A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia
Severe Acute Respiratory Syndrome (SARS-CoV-2) has spread rapidly throughout the world, causing high morbidity and mortality. Analysis of clinical and autopsy data may allow to understand this disease. The results of pulmonary and renal autopsies in 37 deceased patients from COVID-19 are presented.
Materials and methods. An autopsy was performed in Moscow in 37 deceased patients aged from 28 to 94 years. The microscopic features of the lungs and kidneys were examined using hematoxylin and eosin staining.
Results. Important findings include diffuse alveolar injury, pulmonary thrombosis and microangiopathy, as well as acute kidney injury in all cases, varying in severity.
Conclusions. We report the presence of acute kidney injury in all cases, which requires correction of renal function in patients with SARS-CoV-2, with control of serum creatinine levels, urine volume, proteinuria and hematuria.
Materials and methods. An autopsy was performed in Moscow in 37 deceased patients aged from 28 to 94 years. The microscopic features of the lungs and kidneys were examined using hematoxylin and eosin staining.
Results. Important findings include diffuse alveolar injury, pulmonary thrombosis and microangiopathy, as well as acute kidney injury in all cases, varying in severity.
Conclusions. We report the presence of acute kidney injury in all cases, which requires correction of renal function in patients with SARS-CoV-2, with control of serum creatinine levels, urine volume, proteinuria and hematuria.
Keywords: Coronavirus, COVID-19, SARS-CoV-2, autopsy, acute kidney injury, diffuse alveolar damage
About the Autors
Corresponding author: L.V. Reshetov – Ph.D. student at the Department of Urology of A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia; e-mail: leoshtoltz@gmail.com
