Русский
Theoretical basis of the uropatogens interactions with the host-organism in case of occurrence and development of acute pyelonephritis (review – part III)
DOI: https://dx.doi.org/10.18565/urology.2021.4.126-131
M.I. Kogan
Dept. of Urology and Human Reproductive Health (with the Pediatric Urology and Andrology course), Rostov State Medical University, Rostov-on-Don, Russia
The formation and development theories of bacterial inflammation in organs and tissues have been studied in detail and confirmed by experimental and clinical data. However, the development of inflammation in each organ has its characteristics associated with its structures and functions. This fully applies to acute pyelonephritis.
The peculiar structure of uropathogens, their virulence, the reaction of the host organism in response to bacterial invasion, namely, factors of innate and acquired immunity, are analyzed in detail in the review. It reflects both the basic mechanisms of development of acute pyelonephritis and proteomic and genetic factors involved during inflammatory lesions.
The peculiar structure of uropathogens, their virulence, the reaction of the host organism in response to bacterial invasion, namely, factors of innate and acquired immunity, are analyzed in detail in the review. It reflects both the basic mechanisms of development of acute pyelonephritis and proteomic and genetic factors involved during inflammatory lesions.
Keywords: the pathophysiology of the host-organism reaction, toxins and virulence genes of uropathogens, acute pyelonephritis, genetic predisposition
About the Autors
Corresponding author: Mikhail I. Kogan – Honored Scientist of the Russian Federation, M.D., Dr. Sc. (M), Full Prof.; Head, Dept. of Urology and Human Reproductive Health (with the Pediatric Urology and Andrology course), Rostov State Medical University, Rostov-on-Don, Russia; e-mail: dept_kogan@mail.ru
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