The aim of the study to analyze the effectiveness of endoscopic intravesical methods of treatment of women with primary bladder pain syndrome (PBPS).
Materials and methods. 145 women in the age 19 to 79 years (mean age 43.9 ± 3.1 years) with confirmed diagnosis of PBPS were treated. The treatment stages were divided into 4 consecutive lines. The first line of treatment included behavioral and pharmacotherapy, the second was hydrodistension of the bladder, the third was intravesical botulinum therapy (intravesical injections of botulinum toxin type A at 20 points of the bladder wall, 5 U each, total dose 100 U), the fourth was laser ablation of Hunner’s lesions. Evaluation of the effectiveness was carried out one month after the start of treatment measures for each stage of treatment. Improvement of the patient’s quality of life by at least 1 point according to the QoL questionnaire was used as a criterion for the effectiveness of treatment.
Results. Conservative treatment was effective only in 21 (14.4%) out of 145 treated patients. The remaining 124 patients underwent bladder hydrodistension, the positive results were recognized in 46 (37.1%) patients. Botulinum therapy was effective in 41 (52.5%) of 78 treated patients with PBPS refractory to the previous lines of treatment. Laser ablation of Hunner’s lesions of the bladder was performed in the remaining 37 patients, that procedure was effective in 28 (75.1%) patients.
Conclusion. The results of the study showed high efficiency and good tolerance of endoscopic intravesical methods of treatment of women with PBPS.

Keywords: intravesical botulinum therapy, hydrodistension of the bladder, primary bladder pain syndrome, laser ablation, interstitial cystitis