This review is devoted to specific features of diagnosis and treatment of non-gonococcal urethritis caused by intracellular microorganisms.
Using modern literature data and the up-to-date clinical guidelines, an analysis of changes in the epidemiological structure and resistance of intracellular pathogens in non-gonococcal urethritis has been carried out.
The current principles of diagnosis and treatment of non-gonococcal urethritis are reviewed, with a discussion of the place of new molecular genetic methods for detecting the resistance of some intracellular pathogens (Mycoplasma genitalium) in routine clinical practice.
Treatment regimens proposed by various clinical guidelines are compared and critically appraised in the review. Both clinical data and the results of in vitro studies on the efficiency of various drugs against certain intracellular pathogens of urethritis are presented.

Keywords: moxifloxacin, effective antibiotic therapy, non-gonococcal urethritis, antibiotic resistance, clinical guidelines