Русский
A novel method for non-invasive mechanical ablation of prostate tumors using pulsed focused ultrasound
DOI: https://dx.doi.org/10.18565/urology.2019.6.67-73
V.A. Khokhlova, P.B. Rosnitskiy, S.A. Tsysar, S.V. Buravkov, O.A. Sapozhnikov, M.M. Karzova, T.D. Khokhlova, A.D. Maxwell, N.M. Gaifullin, A.V. Kadrev, D.A. Okhobotov, A.A. Kamalov, G.R. Schade
1) Physics Faculty, Lomonosov Moscow State University, Moscow, Russia; 2) Center for Industrial and Medical Ultrasound, University of Washington, Seattle, USA; 3) Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russia; 4) Department of Urology, University of Washington, Seattle, USA; 5) Medical Research and Educational Center, Lomonosov Moscow State University, Moscow, Russia
Aim of the study: demonstrate the feasibility of non-invasive mechanical disintegration of human prostate tissue using pulsed high-intensity focused ultrasound (pHIFU), a method termed boiling histotripsy.
Materials and methods. An ultrasound experimental system was developed for producing localized mechanical lesions in ex vivo biological tissue samples under ultrasound guidance. A series of experiments was carried out to create small single-focus lesions (volume < 2 mm3) and one large lesion (volume > 50 mm3) in ex vivo prostate tissue samples. After irradiation, two samples were bisected to visualize the region of destruction; the other tissue samples were examined
histologically.
Results. During pHIFU irradiation under B-mode ultrasound guidance, a region of increased echogenicity caused by formation of vapor-gas bubbles was visualized in the target region. After exposure, small and large lesions filled with a suspension of liquefied tissue were observed. Histological examination confirmed that the prostate tissue in the focal region was disintegrated into subcellular fragments.
Conclusion. A pilot study showed the feasibility of using boiling histotripsy as a non-invasive method for treating prostate diseases.
Materials and methods. An ultrasound experimental system was developed for producing localized mechanical lesions in ex vivo biological tissue samples under ultrasound guidance. A series of experiments was carried out to create small single-focus lesions (volume < 2 mm3) and one large lesion (volume > 50 mm3) in ex vivo prostate tissue samples. After irradiation, two samples were bisected to visualize the region of destruction; the other tissue samples were examined
histologically.
Results. During pHIFU irradiation under B-mode ultrasound guidance, a region of increased echogenicity caused by formation of vapor-gas bubbles was visualized in the target region. After exposure, small and large lesions filled with a suspension of liquefied tissue were observed. Histological examination confirmed that the prostate tissue in the focal region was disintegrated into subcellular fragments.
Conclusion. A pilot study showed the feasibility of using boiling histotripsy as a non-invasive method for treating prostate diseases.
Keywords: boiling histotripsy, non-invasive procedure, histology, HIFU, benign prostatic hyperplasia, prostate cancer, ultrasound
About the Autors
Corresponding author: V.A. Khokhlova – DSc in Physics, Associate professor, Department of Acoustics, Physics Faculty, Lomonosov Moscow State University, Moscow, Russia; e-mail: vera@acs366.phys.msu.ru
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