Русский
Long-term results of radical surgery treatment of patients with bladder cancer
DOI: https://dx.doi.org/10.18565/urology.2021.3.104-109
B.K. Komyakov, A.V. Sergeev, V.A. Fadeev, T.H. Al-Attar, E.O. Stetsik, A.Y. Ulyanov, Y.S. Savashinsky, O.A. Kirichenko, L.M. Rodygin
1) Federal State Budgetary Educational Institution of Higher Education “North West State University n.a. I.I. Mechnikov”, urology department (Head of department prof. B.K. Komyakov), Saint Petersburg, Russia; 2) Multiprofile city hospital#2 (Head physician prof. V.A.Volchkov), Urology department. Saint-Petersburg, Russia
Purpose. To investigate long-term results after radical cystectomy in patients with bladder cancer.
Materials and methods. Since 1997 to 2020 yy. we have performed 404 radical cystectomy with different methods of derivation for patients with bladder cancer in our clinic. There were 342 (86,4%) men and 62 (13,6%) women. Laboratory study, ultrasound, X-ray, CT. MRI investigations were performed in all patients.
Results. Mortality rate was 2,9%. Early and late postoperative complications have occurred in 136 (33,6%) and 98 (41,8%) cases, respectively. Local recurrence has occurred in 33 (8,5%) patients. 10-years overall and cancer-specific survival were 43,4% and 47,2%, respectively. In lymph-negative patients 2-years and 5-years overall survival were 81,2% and 67,2%, respectively. In lymph positive patients 2-years and 5-years overall survival were 46,9% and 13,9%, respectively. In lymph-negative patients 2-years and 5-years cancer-specific survival were 83,6% and 70,7%, respectively. In lymph positive patients 2-years and 5-years cancer-specific survival were 51,0% and 15,1%, respectively. Overall and cancer –specific survival decreased according to increasing pT-stage and histopathologic grade.
Conclusions: pT–stage (pT), lymp nodes status (pN), histopathologic grade ( pG) have a significant independent influence on overall and cancer-specific survival of bladder cancer patients after radical cystectomy.
Materials and methods. Since 1997 to 2020 yy. we have performed 404 radical cystectomy with different methods of derivation for patients with bladder cancer in our clinic. There were 342 (86,4%) men and 62 (13,6%) women. Laboratory study, ultrasound, X-ray, CT. MRI investigations were performed in all patients.
Results. Mortality rate was 2,9%. Early and late postoperative complications have occurred in 136 (33,6%) and 98 (41,8%) cases, respectively. Local recurrence has occurred in 33 (8,5%) patients. 10-years overall and cancer-specific survival were 43,4% and 47,2%, respectively. In lymph-negative patients 2-years and 5-years overall survival were 81,2% and 67,2%, respectively. In lymph positive patients 2-years and 5-years overall survival were 46,9% and 13,9%, respectively. In lymph-negative patients 2-years and 5-years cancer-specific survival were 83,6% and 70,7%, respectively. In lymph positive patients 2-years and 5-years cancer-specific survival were 51,0% and 15,1%, respectively. Overall and cancer –specific survival decreased according to increasing pT-stage and histopathologic grade.
Conclusions: pT–stage (pT), lymp nodes status (pN), histopathologic grade ( pG) have a significant independent influence on overall and cancer-specific survival of bladder cancer patients after radical cystectomy.
About the Autors
Correspoding author: A.V. Sergeev – Dr. Med. Sci., professor of the department of urology Federal State Budgetary Educational Institution of Higher Education “North West State University n.a. I.I. Mechnikov”, Saint Petersburg, Russia, e-mail: urolsergeev@gmail.com
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