Introduction. Chronic postcoital cystitis is considered as a type of chronic cystitis. The European Association of Urology and the Russian Society of Urology recommend to prescribe antibiotics if behavioral therapy and non-antimicrobial prophylaxis are ineffective. For the prevention of recurrences of postcoital cystitis, it is recommended to use combinations of substances that have an immunoprotective effect, improve the trophism of the bladder mucosa and have an antimicrobial effect. The dietary supplement Uronext contains D-mannose 2000 mg, proanthocyanidins 36 mg (or 500 mg of branded Cran-Max cranberry extract concentrate) and vitamin D3 1 mcg. Considering their properties and the results of previous studies, we carry out our own trial.
Aim. To evaluate the efficiency of the biological additive Uronext for the prevention of recurrent postcoital cystitis in women in parallel-group study.
Materials and methods. A total of 86 women were randomized into 2 groups of 43 patients (group 1, interventional and group 2, control). In the group 1 patients received Uronext one sachet once after each sexual intercourse, while in the group 2 women did not receive prophylactic treatment. The follow-up period was 180 days.
Results. During the follow-up, we noted that Uronext reduced the frequency of relapses of postcoital cystitis by 3 times. The dietary supplement was well tolerated by patients.
Conclusions. Based on our data, we can conclude that the use of Uronext according to the scheme of one sachet once after sexual intercourse for 6 months allows to effectively influence pathogenesis of postcoital cystitis, reduce the frequency of recurrences, thereby significantly improving the quality of life of patients.

Keywords: ronext, postcoital cystitis, D-mannose, cranberry extract, vitamin D