Genitourinary adverse events in men using nonmedical testosterone preparations


DOI: https://dx.doi.org/10.18565/urology.2022.3.92-97

Kh.S. Ibishev, N.I. Volkova, Z.R. Gusova, P.A. Evseev, M.I. Kogan

Rostov State Medical University, Rostov-on-Don, Russia
Introduction. In recent years, there has been an active use of testosterone preparations (PT) and anabolic steroids (AS) by athletes for non-medical purposes, against the background of which undesirable effects from the urinary tract and organs of the reproductive system are recorded.
Target. To study the structure of adverse events (AE) from the urinary tract and genital organs in men who attended gyms and used testosterone preparations and anabolic steroids for non-medical purposes.
Materials and methods: A clinical and statistical analysis of 64 men aged 22-46 years was carried out. Prior to the start of PT, all men had no history of diseases from the urinary tract and reproductive organs.
When substantiating patients, validated questionnaire scales were used: International Prostatic Symptom Score (IPSS) and International Index of Erectile Function (IIEF5) and laboratory and instrumental research methods: microscopic examination of the ejaculate, studies of Total Tc, FSH, LH, prolactin, estradiol in blood serum, and ultrasound with Doppler mapping of the vessels of the penis.
Results: Erectile dysfunction, marital infertility, and testicular hypotrophy were found to be among the adverse events. Less common are LUTS, anejaculation, and gynecomastia. In isolated cases, CKD and a testicular tumor were detected.
Conclusion. Unreasonable therapy of PT and AS can be accompanied by a wide range of various adverse events in the urinary tract and organs of the reproductive system of urination. The negative effects of this practice should be explained to men. It is important to develop a system for the treatment of AEs.

About the Autors


Corresponding author: Kh.S. Ibishev – PhD in Medical Sciences, Professor of Department of Urology and Human Reproductive Health with a course in Pediatric Urology-Andrology, Rostov state medical university, Rostov-on-don, Russia; e-mail: ibishev22@mail.ru


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