The results of studies comparing the therapy of benign prostatic hyperplasia with 5α-reductase inhibitors and α1-blockers are presented in the article. Benign prostatic hyperplasia is a common disease in older men. Pathogenetic treatment allows to block a progression of prostatic hyperplasia and is of greatest interest in the treatment of this disease. The obtained data reliably demonstrate the advantage and safety of long-term pathogenetic therapy with dutasteride compared with symptomatic tamsulosin monotherapy with regard to quality of life and subjective symptoms. In addition, pathogenetic therapy provides better results in preventing the progression of benign prostatic hyperplasia.

Keywords: Gardium, dutasteride, 5α-reductase inhibitors, acute urinary retention, BPH, α-adrenoblockers