Русский
Immunological parameters of urine in differential diagnosis of chronic recurrent cystitis in women
DOI: https://dx.doi.org/10.18565/urology.2024.1.10-16
Ibishev Kh.S., Mamedov V.K., Migacheva N.B., Kogan M.I.
1) Rostov State Medical University, Rostov-on-Don, Russian Federation; 2) Samara State Medical University, Samara, Russian Federation
Introduction. Chronic recurrent cystitis (CRC) is a complex multifaceted problem of modern uroinfectology.
Objective. To study the immunological parameters of urine in patients with chronic recurrent cystitis depending on the etiological factor.
Materials and methods. The prospective study included 71 patients aged 20–45 years who had previously been diagnosed with recurrent lower urinary tract infection: chronic recurrent cystitis (CRC) during an exacerbation period. Based on the results of bacteriological and PCR studies of urine, scraping of the urethra and vagina, depending on the dominant etiological factor, the patients were divided into three groups: group 1 (n=30) – with papillomavirus CRC (PVI-CRC), group 2 (n=30) – with bacterial CRC (B – CRC), group 3 (n=11) – with candida CRC (C – CRC). Analysis of the assessment of immunological parameters of urine was carried out using an enzyme-linked immunosorbent assay (ELISA-BEST).
Results. Based on the results of an immunological study of urine in the study groups, characteristic specific changes in the level of interleukins and interferons were identified, which made it possible to determine a protocol for the differential diagnosis of CRC.
Conclusions. Our study shows the advisability of testing interleukins in urine (IL-1 beta, IL-6, IL-8); these indicators can serve as scoring criteria in the differential diagnosis of CRC of various origins.
Conclusions, it is reasonable to study the level of IFNα-2b and IFNγ; when identifying the functional inferiority of the IFN system in women with CRC, correction of the IFN system is necessary.
Objective. To study the immunological parameters of urine in patients with chronic recurrent cystitis depending on the etiological factor.
Materials and methods. The prospective study included 71 patients aged 20–45 years who had previously been diagnosed with recurrent lower urinary tract infection: chronic recurrent cystitis (CRC) during an exacerbation period. Based on the results of bacteriological and PCR studies of urine, scraping of the urethra and vagina, depending on the dominant etiological factor, the patients were divided into three groups: group 1 (n=30) – with papillomavirus CRC (PVI-CRC), group 2 (n=30) – with bacterial CRC (B – CRC), group 3 (n=11) – with candida CRC (C – CRC). Analysis of the assessment of immunological parameters of urine was carried out using an enzyme-linked immunosorbent assay (ELISA-BEST).
Results. Based on the results of an immunological study of urine in the study groups, characteristic specific changes in the level of interleukins and interferons were identified, which made it possible to determine a protocol for the differential diagnosis of CRC.
Conclusions. Our study shows the advisability of testing interleukins in urine (IL-1 beta, IL-6, IL-8); these indicators can serve as scoring criteria in the differential diagnosis of CRC of various origins.
Conclusions, it is reasonable to study the level of IFNα-2b and IFNγ; when identifying the functional inferiority of the IFN system in women with CRC, correction of the IFN system is necessary.
About the Autors
Corresponding author: Kh.S. Ibishev – M.D., Dr. Sc. (Med), Full Prof.; Prof. Dept. of Urology, Pediatric Urology & Reproductive Health, Rostov State Medical University, Rostov-on-Don, Russian Federation, e-mail: ibishev22@mail.ru
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