Гиперактивный мочевой пузырь у сложного пациента: какой препарат выбрать?


DOI: https://dx.doi.org/10.18565/urology.2021.1.120-125

Е.В. Кульчавеня, Д.П. Холтобин

1) ФГБУ Новосибирский НИИ туберкулза Минздрава России, Новосибирск, Россия; 2) Медицинский центр «Авиценна», Новосибирск, Россия
Проведен обзор литературы, включивший 60 отечественных и зарубежных источников. В обзоре сделан упор на аспекты патогенеза и патофизиологии гиперактивного мочевого пузыря (ГАМП), показано влияние гиперактивности мочевого пузыря на сексуальную функцию женщины, отражены особенности лечения ГАМП у коморбидных пациентов и осложнения терапии холинэргическими препаратами.
Анализ показал, что существующие лекарственные препараты высокоэффективны, но чреваты развитием нежелательных побочных реакций. Допустимо сочетание как различных М-холинолитиков, так и М-холинолитиков с α-адреноблокаторами и агонистами β3-адренорецепторов. Пациентам старшего возраста, особенно с когнитивными нарушениями и деменцией, пациентам, получающим по поводу сопутствующих заболеваний препараты, метаболизирующиеся с участием цитохрома Р-450, больным туберкулезом мочевого пузыря следует предпочесть троспия хлорид.

Литература


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Об авторах / Для корреспонденции


А в т о р д л я с в я з и: Е. В. Кульчавеня – д.м.н., профессор, главный научный сотрудник ФГБУ «Новосибирский НИИ туберкулеза» Минздрава России, руководитель отдела урологии ННИИТ, профессор кафедры туберкулеза НГМУ, Новосибирск, Россия; e-mail: urotub@yandex.ru


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