Предикторы эффективности терапии ингибиторами контрольных точек иммунного ответа при светлоклеточной почечно-клеточной карциноме


DOI: https://dx.doi.org/10.18565/urology.2023.6.122-126

Гилязова И.Р., Измайлов А.А., Асадуллина Д.Д., Иванова Е.А., Павлов В.Н., Хуснутдинова Э.К.

1) ФГБУН «Институт биохимии генетики Уфимского научного центра Российской академии наук», Уфа, Россия; 2) ФГБОУ ВО «Башкирский государственный медицинский университет» Министерства здравоохранения Российской Федерации, Уфа, Россия; 3) ГАУЗ «Республиканский клинический онкологический диспансер» МЗ РБ, Уфа, Россия
Иммунотерапия онкологических заболеваний включает применение методов лечения для стимуляции иммунной системы и косвенного подавления роста опухолевых клеток. Применение иммуннотерапевтических препаратов позволило расширить возможности лечения онкологических больных. Несмотря на впечатляющий успех, достигнутый в разработке ингибиторов контрольной точки иммунитета (ИКТИ), большинство пациентов не демонстрируют ответа на терапию. Имеющиеся на данный момент маркеры эффективности являются неспецифичными. Для наиболее эффективного и экономичного применения ИКТИ важно идентифицировать специфичные биомаркеры, которые позволят предсказать терапевтический ответ на терапию с высокой точностью и специфичностью. Особый интерес представляют микроРНК, которые регулируют экспрессию генов, вовлечены в процесс канцерогенеза и резистентности к терапии. В статье проведены анализ и обобщение результатов исследований молекулярно-генетических изменений у пациентов с почечно-клеточной карциномой (ПКК) с целью их возможного использования в качестве прогностических биомаркеров при назначении терапии ИКТИ.

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Об авторах / Для корреспонденции


А в т о р д л я с в я з и: И. Р. Гилязова – старший научный сотрудник ФГБУН «Институт биохимии и генетики Уфимского научного центра Российской академии наук», Уфа, Россия; e-mail: gilyasova_irina@mail.ru


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