English
Влияние курения электронных сигарет на мужскую репродуктивную систему и сперматогенез
DOI: https://dx.doi.org/10.18565/urology.2024.5.116-121
Белый Л.Е.
ФГБОУ ВО «Ульяновский государственный университет», Ульяновск, Россия
В настоящем обзоре представлены новые научные данные, касающиеся влияния основных компонентов жидкости для электронных сигарет на мужскую репродуктивную систему и сперматогенез. Предоставлены результаты экспериментальных исследований, доказывающих негативное влияние аэрозоля электронных сигарет на клеточную организацию семенных канальцев и систему гормональной регуляции сперматогенеза. Проанализированы клинические исследования, результаты которых не позволяют воспринимать вейпинг как безопасную альтернативу традиционному курению в случае планирования мужчиной отцовства и подготовки к зачатию ребенка.
Литература
1. Inhorn M.C., Patrizio P. Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century. Hum. Reprod. Update. 2015;21:411–426. https://doi.org/10.1093/humupd/dmv016
2. Rutstein S.O., Shah I.H. Infecundity, infertility, and childlessness in developing countries; Calverton, Maryland, USA: ORC Macro and the World Health Organization; 2004. DHS comparative reports No.9.
3. Bozhedomov V.A. The male factor in childness marriage - problem-solving strategies. Urologiia. 2016;1 (Suppl. 1):28–34. Russian (В.А. Божедомов). Мужской фактор бездетного брака – пути решения проблемы. Урология. 2016; 1 (приложение 1): 28–34).
4. World Health Organization. WHO Manual for the Standardized Investigation and Diagnosis of the Infertile Couple. 2000, Cambridge University Press: Cambridge.
5. Trummer H., Habermann H., Haas J., Pummer K. The impact of cigarette smoking on human semen parameters and hormones. Hum. Reprod. 2002;17(6):1554–1559. https://doi.org/10.1093/humrep/17.6.1554
6. Li Y., Lin H., Li Y., Cao J. Association between socio-psycho-behavioral factors and male semen quality: systematic review and meta-analyses. Fertil. Steril. 2011;95(1):116–123. https://doi.org/10.1016/j.fertnstert.2010.06.031
7. Osadchuk L.V., Popova A.V., Erkovich A.A., Voroshilova N.A., Osadchuk A.V. Effects of smoking and alcohol consumption on reproductive and metabolic indicators in young men in Western Siberia. Urologiia. 2017;4:62–67. Russian (Осадчук Л.В., Попова А.В., Еркович А.А., Ворошилова Н.А., Осадчук А.В. Влияние курения и алкоголя на репродуктивные и метаболические показатели у молодых мужчин Западной Сибири. Урология. 2017;4:62–67). https://dx.doi.org/10.18565/urol.2017.4.62–67
8. Chen R., Pierce J.P., Leas E.C., Benmarhnia T., Strong D.R., White M.M., Stone M., Trinidad D.R., McMenamin S.B., Messer K. Effectiveness of e-cigarettes as aids for smoking cessation: evidence from the PATH Study cohort, 2017-2019. Tob. Control. 2023;32(e2):e145-e152. https://doi.org/10.1136/tobaccocontrol-2021-056901
9. Sapru S., Vardhan M., Li Q., Guo Y., Li X., Saxena D. E-cigarettes use in the United States: Reasons for use, perceptions, and effects on health. BMC Public Health. 2020;20:1518. https://doi.org/10.1186/s12889-020-09572-x
10. Podzolkov V.I., Vetluzhskaya M.V., Abramova A.A., Ishina T.I., Garifullina K.I. Vaping and vaping-associated lung injury: a review. Terapevticheskii arkhiv. 2023;95(7):591–596. Russian. (Подзолков В.И., Ветлужская М.В., Абрамова А.А., Ишина Т.И., Гарифуллина К.И. Вейпинг и вейп-ассоцированное поражение легких. Терапевтический архив. 2023;95(7): 591–596) https://doi.org/10.26442/00403660.2023.07.202293
11. Montjean D., Godin Pagé M.H., Bélanger M.C., Benkhalifa M., Miron P. An overview of E-cigarette impact on reproductive health. Life (Basel). 2023;13(3):827. https://doi.org/10.3390/life13030827
12. Szumilas K., Szumilas P., Grzywacz A., Wilk A. The Effects of E-сigarette vapor components on the morphology and function of the male and female reproductive systems: a systematic review. Int. J. Environ. Res. Public Health. 2020;17(17):6152. https://doi.org/10.3390/ijerph17176152
13. Spindle T.R., Eissenberg T. Pod Mod electronic cigarettes-an emerging threat to public health. JAMA Netw. Open. 2018;1(6):e183518. https://doi.org/10.1001/jamanetworkopen.2018.3518
14. Pisinger C., Dossing M. A systematic review of health effects of electronic cigarettes. Prev. Med. 2014;69:248–260. https://doi.org/10.1016/j.ypmed.2014.10.009
15. Dai J.B., Wang Z.X., Qiao Z.D. The hazardous effects of tobacco smoking on male fertility. Asian J. Androl. 2015;17(6):954-960. https://doi.org/10.4103/1008-682X.150847
16. Sofikitis N., Takenaka M., Kanakas N., Papadopoulos H., Yamamoto Y., Drakakis P., Miyagawa I. Effects of cotinine on sperm motility, membrane function, and fertilizing capacity in vitro. Urol. Res. 2000;28(6):370–375. https://doi.org/10.1007/s002400000138
17. Oyeyipo I.P., Maartens P.J., du Plessis S.S. In vitro effects of nicotine on human spermatozoa. Andrologia. 2014;46(8):887–892. https://doi.org/10.1111/and.12169
18. Kim K.H., Joo K.J., Park H.J., Kwon C.H., Jang M.H., Kim C.J. Nicotine induces apoptosis in TM3 mouse Leydig cells. Fertil. Steril. 2005;83(Suppl. 1):1093–1099. https://doi.org/10.1016/j.fertnstert.2004.12.013
19. Nesseim W.H., Haroun H.S., Mostafa E., Youakim M.F., Mostafa T. Effect of nicotine on spermatogenesis in adult albino rats. Andrologia. 2011;43(6):398–404. https://doi.org/10.1111/j.1439-0272.2010.01086.x
20. Benowitz N.L. Clinical pharmacology of nicotine: implications for understanding, preventing, and treating tobacco addiction. Clin. Pharmacol. Ther. 2008;83(4):531–541. https://doi.org/10.1038/clpt.2008.3
21. Goniewicz M.L., Kuma T., Gawron M., Knysak J., Kosmider L. Nicotine levels in electronic cigarettes. Nicotine Tob. Res. 2013;15(1):158–166. https://doi.org/10.1093/ntr/nts103
22. Duell A.K., Pankow J.F.., Peyton D.H. Nicotine in tobacco product aerosols: ‘It’s déjà vu all over again’. Tob. Control. 2020;29(6):656–662. https://doi.org/10.1136/tobaccocontrol-2019-055275
23. Effah F., Taiwo B., Baines D., Bailey A., Marczylo T. Pulmonary effects of e-liquid flavors: a systematic review. J. Toxicol. Environ. Health. B. Crit. Rev. 2022;25(7):343–371. https://doi.org/10.1080/10937404.2022.2124563
24. Zhu S.H., Sun J.Y., Bonnevie E., Cummins S.E., Gamst A., Yin L., Lee M. Four hundred and sixty brands of e-cigarettes and counting: implications for product regulation. Tob. Control. 2014;23 Suppl 3:iii3-9. https://doi.org/10.1136/tobaccocontrol-2014-051670
25. Tierney P.A., Karpinski C.D., Brown J.E., Luo W., Pankow J.F. Flavour chemicals in electronic cigarette fluids. Tob. Control. 2016;25(e1):e10–15. https://doi.org/10.1136/tobaccocontrol-2014-052175
26. Fetterman J.L., Weisbrod R.M., Feng B., Bastin R., Tuttle S.T., Holbrook M., Baker G., Robertson R.M., Conklin D.J., Bhatnagar A., Hamburg N.M. Flavorings in tobacco products induce endothelial cell dysfunction. Arterioscler. Thromb. Vasc. Biol. 2018;38(7):1607–1615. https://doi.org/10.1161/ATVBAHA.118.311156
27. Behar R.Z., Luo W., McWhirter K.J., Pankow J.F., Talbot P. Analytical and toxicological evaluation of flavor chemicals in electronic cigarette refill fluids. Sci Rep. 2018;8(1):8288. https://doi.org/10.1038/s41598-018-25575-6
28. Behar R.Z., Luo W., Lin S.C., Wang Y., Valle J., Pankow J.F., Talbot P. Distribution, quantification and toxicity of cinnamaldehyde in electronic cigarette refill fluids and aerosols. Tob. Control. 2016;25(Suppl 2):ii94-ii102. https://doi.org/10.1136/tobaccocontrol-2016-053224
29. Wang H.X., Li H.C., Lv M.Q., Zhou D.X., Bai L.Z., Du L.Z., Xue X., Lin P., Qiu S.D. Associations between occupation exposure to formaldehyde and semen quality, a primary study. Sci. Rep. 2015;5:15874. https://doi.org/10.1038/srep15874
30. O’Neill H. Effect of electronic-cigarette flavourings on (I) human sperm motility, chromatin integrity in vitro and (II) mice testicular function in vivo. [(accessed on 01 February 2024) http://srf-reproduction.org/wp-content/uploads/2017/01/Fertility-2017-Final-Programme-and-Abstracts.pdf
31. Ooi B.G., Dutta D., Kazipeta K., Chong N.S. Influence of the E-cigarette emission profile by the ratio of glycerol to propylene glycol in e-liquid composition. ACS Omega. 2019;4(8):13338–13348. https://doi.org/10.1021/acsomega.9b01504
32. National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee on the Review of the Health Effects of Electronic Nicotine Delivery Systems. Public Health Consequences of E-Cigarettes. Eaton D.L., Kwan L.Y., Stratton K., editors. Washington (DC): National Academies Press (US); 2018.
33. Wiebe J.P., Barr K.J. The control of male fertility by 1,2,3-trihydroxypropane (THP;glycerol): rapid arrest of spermatogenesis without altering libido, accessory organs, gonadal steroidogenesis, and serum testosterone, LH and FSH. Contraception. 1984;29(3):291–302. https://doi.org/10.1016/s0010-7824(84)80009-8
34. Igdoura S.A., Wiebe J.P. Suppression of spermatogenesis by low-level glycerol treatment. J. Androl. 1994;15(3):234–243.
35. Immegart H.M., Threlfall W.R. Evaluation of intratesticular injection of glycerol for nonsurgical sterilization of dogs. Am. J. Vet. Res. 2000;61(5):544–549. https://doi.org/10.2460/ajvr.2000.61.544
36. El Golli N., Rahali D., Jrad-Lamine A., Dallagi Y., Jallouli M., Bdiri Y., Ba N., Lebret M., Rosa J.P., El May M., El Fazaa S. Impact of electronic-cigarette refill liquid on rat testis. Toxicol. Mech. Methods. 2016;26(6):427–434. https://doi.org/10.3109/15376516.2016.1163448
37. Rahali D., Jrad-Lamine A., Dallagi Y., Bdiri Y., Ba N., El May M., El Fazaa S., El Golli N. Semen parameter alteration, histological changes and role of oxidative stress in adult rat epididymis on exposure to electronic cigarette refill liquid. Chin. J. Physiol. 2018;61(2):75–84. https://doi.org/10.4077/CJP.2018.BAG521
38. Vivarelli F., Canistro D., Cirillo S., Cardenia V., Rodriguez-Estrada M.T., Paolini M. Impairment of testicular function in electronic cigarette (e-cig, e-cigs) exposed rats under low-voltage and nicotine-free conditions. Life Sci. 2019;228:53–65. https://doi.org/10.1016/j.lfs.2019.04.059
39. Fajariyah S., Utami E.T., Sa’adah N. Effect of electric cigarette smoke exposure on spermatozoa quality of mice (Mus musculus L). Int. J. Adv. Eng. Res. Sci. 2021;8:371–374. https://doi.org/10.22161/ijaers.812.38
40. Saygın H., Korgalı E., Koç T., Doğan K. The effect of smoking and electronic cigarettes on rat testicles. Rev. Int. Androl. 2023;21(3):100365. https://doi.org/10.1016/j.androl.2023.100365
41. Abdel-Kareem R.H., Deraz R.H., Refaay N.E. Impact of electronic cigarette exposure on thetTestes of adult male albino rat and the role of cessation: histopathological and biochemical study. Zagazig. Univ. Med. J. 2022;28:855–870.
42. Holmboe S.A., Priskorn L., Jensen T.K., Skakkebaek N.E., Andersson A.M., Jørgensen N. Use of e-cigarettes associated with lower sperm counts in a cross-sectional study of young men from the general population. Hum. Reprod. 2020;35(7):1693–1701. https://doi.org/10.1093/humrep/deaa089
43. Shiels M.S., Rohrmann S., Menke A., Selvin E., Crespo C.J., Rifai N., Dobs A., Feinleib M., Guallar E., Platz E.A. Association of cigarette smoking, alcohol consumption, and physical activity with sex steroid hormone levels in US men. Cancer Causes Control. 2009;20(6):877–886. https://doi.org/10.1007/s10552-009-9318-y
44. Holmboe S.A., Vradi E., Jensen T.K., Linneberg A., Husemoen L.L., Scheike T., Skakkebæk N.E., Juul A., Andersson A.M. The association of reproductive hormone levels and all-cause, cancer, and cardiovascular disease mortality in men. J. Clin. Endocrinol. Metab. 2015;100(12):4472–4480. https://doi.org/10.1210/jc.2015-2460
45. Biegon A., Alia-Klein N., Fowler J.S. Potential contribution of aromatase inhibition to the effects of nicotine and related compounds on the brain. Front Pharmacol. 2012;3:185. https://doi.org/10.3389/fphar.2012.00185.
46. Lee J.I.L., Lim C.K., Sung S. Comparison of sperm DNA fragmentation (DFI) among non-smorkers, regular smorkers, electronic cigarette (E-cigarette) smorkers and regular/E-cigarette smorkers. Fertil. Steril. 2022;118:e305. https://doi.org/10.1016/j.fertnstert.2022.09.060
Об авторах / Для корреспонденции
А в т о р д л я с в я з и: Л. Е. Белый – д.м.н., профессор кафедры госпитальной хирургии, анестезиологии, реаниматологии, урологии, травматологии, ортопедии, ФГБОУ ВО «Ульяновский государственный университет», Ульяновск, Россия; e-mail: lbely@yandex.ru
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